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A multi-parameter, feedback-based electrical stimulation system for cardiomyocyte cultures

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4 Author(s)
Whittington, R.H. ; Dept. of Electr. Eng., Stanford Univ., CA, USA ; Gilchrist, K.H. ; Giovangrandi, L. ; Kovacs, G.T.A.

Cardiac myocytes are cultured to confluency on a 36-element planar microelectrode array. Spontaneously-active cardiomyocyte cultures are electrically stimulated, eliciting action potentials (APs), and the resulting data is amplified, filtered, and stimulation artifacts are removed during data acquisition. Stimulation circuitry allows real-time control of stimulation waveform amplitude, duration, and rate via 10-bit digital-to-analog converters (DACs). By extracting artifacts and processing AP properties in real time, we incorporate these properties into real-time stimulation algorithms, creating a sensitive feedback-regulated myocyte-based transducer of cell electrophysiological properties. Applications of this technology include toxin detection, automated pharmaceutical screening, and basic cardiac electrophysiology.

Published in:

TRANSDUCERS, Solid-State Sensors, Actuators and Microsystems, 12th International Conference on, 2003  (Volume:2 )

Date of Conference:

8-12 June 2003