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This paper employs previously developed modeling, validation, and stimulation tools to address, for the first time, the realistic macroscopic simulation of a real large-scale motorway network. More specifically, the macroscopic simulator METANET, involving a second-order traffic flow model as well as network-relevant extensions, is utilized. A rigorous quantitative validation procedure is applied to individual network links, and subsequently a heuristic qualitative validation procedure is employed at a network level. The large-scale motorway network around Amsterdam, The Netherlands, is considered in this investigation. The main goal of the paper is to describe the application approach and procedures and to demonstrate the accuracy and usefulness of macroscopic modeling tools for large-scale motorway networks.