Agents promoting and suppressing acoustic cavitation

In therapeutic application of ultrasound, promotion and suppression of cavitational effects are both important. The authors have reported that rose bengal (RB) can reduce the intensity threshold for cavitation in murine liver tissue. This effect was pharmacokinetically studied here. It decreased gradually as the time elapsed after the RB administration, but not as rapidly as the decrease in RB concentration in the liver. As for chemicals suppressing aqueous cavitation, the authors found that sodium ascorbate is quite effective.