Optimum Size and Volume of Nanoparticles Within Hollow Core Photonic Crystal Fiber

We investigate the effect of volume and size of silver nanoparticles (AgNP) on surface enhanced Raman scattering (SERS) signal of rhodamine 6G (R6G) within hollow core photonic crystal fiber (HC-PCF). The HC-PCF enhanced the Raman signal of R6G by a factor ~90 via photonic band gap. In addition, the optimal size and volume of AgNP enhanced the Raman signal of R6G by a factor of ~43, resulting in a total enhancement of ~4223 in HC-PCF. A comparison of AgNP enhancement factors in HC-PCF and bulk sample (cuvette) is presented at their optimal size and volume with respect to R6G. The SERS based HC-PCF sensing platform as optimized for R6G as a test molecule, was further utilized for monitoring adenosine for clinical application.