A CMOS sensor for in-vivo fluorescence and electrical imaging in a mouse brain

We report a complementary-metal-oxide-semiconductor (CMOS) image sensor for in-vivo imaging. The sensor is implemented on a flexible substrate with LEDs as excitation light sources. The images are successfully obtained in a mouse brain. We demonstrate a image contrast improvement method on the basis of image processing and multiple readout in order to overcome non uniform illumination of the excitation light.