Two-dimensional label-free acetylcholine image sensor for imaging neuronal communication

32times32 acetylcholine image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of acetylcholine distribution was carried out without label and a huge measurement. Acetylcholine imaging technology has a lot of potential for the early stage of Alzheimer's disease, the release mechanism between terminal neurons. In addition, the proposed sensor is a very unique device due to not only determine quantity but also acquire real time imaging of behavior of biological matter. Therefore, the sensor has an infinite of possibility as a new tool in medical and biological field.