The expansion of the market for portable wireless communication devices has given a tremendous push to the development of a new generation of low-power radio frequency integrated circuit (RFIC) products. In this fast-growing environment where time-to-market constraints force tight schedules, having a good design methodology, innovation computer-aided design (CAD) tools, and a well-integrated design system are key factors for success. In this paper, we describe a design system developed to provide the designer with everything necessary to accurately predict the behavior of RFIC devices, including layout and package parasitic effects. We show how important a well-defined and integrated system is to manufacturing a design that meets specifications at the minimum cost, in the minimum time. A close link between schematic, models, and layout is of paramount importance to ensure the accuracy need for low-power RF design. We give an overview of the advanced methods and tools currently available for simulation and noise analysis of RF devices. Finally, we show a design example that obtained first-silicon success.