This paper designed a non-target multi-point calibration method for the quality enhancement of large-area satellite images by using local aerial images. Satellite images are more sensitive to atmospheric effects compared with aerial images. Atmospheric effects on aerial images are even negligible in fine weather. Given that aerial remote sensing has high spatial resolution and geometric fidelity, more spatial details can be recorded in aerial images. However, the scan bandwidth of aerial images is limited compared with that of satellite images. Thus, taking high-quality aerial images of a neighborhood as reference can provide prior knowledge for point spread function (PSF) estimation and for the quality enhancement of large-area satellite images. The least square method and interpolation are used for the PSF estimation of spatial variation, and then total variation minimization is used for recovery. The results show that the designed method can effectively enhance the quality of large-area satellite images.