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This article focuses on a scalable software platform for the Smart Grid cyber-physical system using cloud technologies. Dynamic Demand Response (D2R) is a challenge-application to perform intelligent demand-side management and relieve peak load in Smart Power Grids. The platform offers an adaptive information integration pipeline for ingesting dynamic data; a secure repository for researchers to share knowledge; scalable machine-learning models trained over massive datasets for agile demand forecasting; and a portal for visualizing consumption patterns, and validated at the University of Southern California's campus microgrid. The article examines the role of clouds and their tradeoffs for use in the Smart Grid Cyber-Physical Sagileystem.