Cyber Physical Systems (CPS) promise advances towards smarter critical infrastructure systems significantly enhancing reliability, efficiency and safety. Current CPS Monitoring and Analysis (M&A) technologies are inadequate for realizing effective, pervasive, and efficient defense. Such technologies do not consider that cyber and physical convergence would need a new paradigm that treats cyber and physical components seamlessly. Further, information sharing was always prohibited to maintain the presumed, implicit parameter-defense protection for the Target of Defense (ToD) privacy. These assumptions lead to drastic limitations negatively impacting the quality, reliability, survivability, and promptness of the defense service provisioning. In this paper, we propose an Evolutionary Sensory system EvoSense towards realizing pervasive M&A for heterogeneously composed targets. EvoSense is a biologically-inspired intrinsically-resilient, situation-aware sense and response system to seamlessly effect biological-immune-system-like defense. EvoSense acts as a middle layer between the defense service provider(s) and the ToD creating a uniform defense interface that hides ToD's scale and heterogeneity concerns from control and management. EvoSense is elastic where solutions are dispatched through a dynamic set of sensors and effectors to the ToD rather than using pre-deployed M&A components. EvoSense circulates context-driven, online customizable sensing and effecting capsules into the ToD body to pervasively monitor, analyze and control ToD components. The key design principles are: ToD-independent defense service provisioning; decoupling sensing and effecting tools from the control and management logic towards enabling interoperable and dynamic defense; and intrinsically supporting trustworthy scalable cooperative defense with shared indicators. Using analysis and simulation, our results demonstrate that EvoSense can enhance detection and resolution promptne- s and sensitivity to multi-threaded widespread attacks while saving considerable amount of ToD resources.