Here the authors present the new design of blood filtration system for patients with kidney diseases. The proposed system consists of electronic module, drug delivery part, blood extraction and blood insertion part, blood filtration part, flow sensors and blood pressure sensor. Electronic module provides necessary functionalities and control to other components of system. Using inductively coupled plasma etching technology hollow silicon microneedles have been developed for drug delivery part. Nano porous aluminium membrane has been fabricated for blood filtration part. Ultra-sharp tip polymeric dual radii microneedles have been proposed for blood extraction and insertion part. Using ANSYS, strength modelling, microfluidic static and multifield analyses have been conducted. Water, ethanol and blood have been used as working fluid in microfluidic analysis to foresee the flow rate and viscosity effect through microneedles. Fluidic analysis shows that the proposed design is suitable for blood transport because two different lumens radii in microneedles are useful to avoid the clogging effect because of pressure difference in the lumen regions.