Density-prioritized memories such as NAND-ROM require a longer single-ended bitline (BL) sensing scheme to maintain high cell array efficiency and therefore suffer from a reduced BL sensing margin at ultra-low supply voltages (VDD) for read-0. This is the result of 1) reduced BL discharge driving current due to limited cell size and driving voltage; and 2) a larger BL false drop noise for read-1. This study proposes a data-aware sensing reference (DASR) scheme, capable of maintaining sensing margins for both read-0 and read-1 under given timing constraints. The key mechanism involved in maintaining the sensing margin is the adaptive changing of the reference voltage (VREF), such that the sensing headroom or potential range (VBL-VREF) for read-1 and read-0 overlap, as in differential BL sensing. Two 256 Kb DASR NAND-ROM macros, with and without code-inversion schemes, were fabricated using a 90 nm bulk CMOS logic process. The 256 Kb DASR NAND-ROM macros are functional down to 0.25 V. DASR also increases the access speed by 66.7% at 0.31 V VDD, compared with the conventional approach without the proposed DASR scheme.