Reduction of packet loss in communication network by modifying the transmit queue length is an important research topic. A cross layer aware transmission queue adaptation system of a fixed computing system having multiple physical interfaces is presented here. The proposed system determines the condition of communication channel/network associated with the multiple physical interfaces while transmitting and receiving the data simultaneously through the interfaces. The core functional blocks of the proposed cross layer system modifies the transmission queue length of the active physical interfaces based on their dynamic network condition, and available bandwidth. It does not require any feedback mechanism, as well as intervention of any router or any proxy node. The experimental results show the enhancement in throughput and hence the QoS by using the proposed transmission queue adaptation mechanism using multiple interfaces. A future scope of the present work in detail is also presented here.