The measurement of interaction forces in minimally invasive surgical devices, sensorized with photonic crystal fiber (PCF) sensors, is presented in this paper. Two types of PCF sensors are used: a tapered PCF interferometer and a microhole-collapsed PCF interferometer for the detection of interaction forces generated in surgical devices without the influence of ambient temperature variation. The demonstration devices used for force characterization are a laparoscopic scissor and a standard surgical scissor blade. The force sensitivity of each sensorized blade is examined and compared with fiber Bragg grating (FBG)-sensorized blades. Results show that the PCF-sensorized surgical blades outperform the blades fitted with the FBG sensors during static load measurement.