In large scale cluster system, cluster resource management system is an important part. The data of cluster resource management system related to cluster are stored in resource database. To improve the efficiency of the entire cluster system the operation of the cluster can be optimized by adjusting the performance of the cluster resource database. In this paper, to develop performance tuning tool for cluster resources database is proposed. The design ideas and design processes of performance tuning tool for cluster resources database are illustrated in detail by MySQL database under Linux environment. Finally, the cluster resource database performance tuning is achieved through three interface functions: performance analysis, access to parameters and parameter adjustments.