This paper provides a novel pointwise-adaptive speckle filter based on local homogeneous-region segmentation with pixel-relativity measurement. A ratio distance is proposed to measure the distance between two speckled-image patches. The theoretical proofs indicate that the ratio distance is valid for multiplicative speckle, while the traditional Euclidean distance failed in this case. The probability density function of the ratio distance is deduced to map the distance into a relativity value. This new relativity-measurement method is free of parameter setting and more functional compared with the Gaussian kernel-projection-based ones. The new measurement method is successfully applied to segment a local shape-adaptive homogeneous region for each pixel, and a simplified strategy for the segmentation implementation is given in this paper. After segmentation, the maximum likelihood rule is introduced to estimate the true signal within every homogeneous region. A novel evaluation metric of edge-preservation degree based on ratio of average is also provided for more precise quantitative assessment. The visual and numerical experimental results show that the proposed filter outperforms the existing state-of-the-art despeckling filters.