We present N2Cloud, a novel Cloud-based neural network simulation system, which provides and exchanges neural network knowledge and simulation resources to and between arbitrary users on a world-wide basis following the Web 2.0 principle. N2Cloud enables the exchange of knowledge, as neural network objects and paradigms, by a virtual organization environment and delivers ample resources by exploiting the Cloud computing principle. The system provides a transparent environment to allow even naive users to exploit the resources of this simulation system. N2Cloud uses standard protocols and is based on a pure service oriented approach. Hereby it integrates into the up-to-date service stack (SaaS, PaaS, and IaaS) of service oriented architectures.