In this work, we report a comparative study of quartz crystal microbalance sensors for Cardiac marker detection. These sensors are deposited with two different polymers, polyvinylchroride (PVC) and polyethylenemine (PEI) using spray coating technique for preparation of adsorption surface. The AFM measurements show that the maximum RMS roughness of coated films occur at around 20 seconds of deposition time, under spraying pressure of 1 bar using precursors concentration of 1% w/v. The results indicate that PEI is far superior to PVC in term of surface roughness which is corresponding to the presence of micropores. The hydrophilic properties between these two materials confirm that PEI have a higher potentials of attracting bimolecular due to a lower contact angle to a droplet of DI water. The absorption of proteins A (103 molecules) suspension on PEI surface is verified by a SEM image.