The substrate-induced strain effect in La7/8Sr1/8MnO3 (LSMO) thin films grown on (001)-oriented SrTiO3 and ferroelectric 0.7Pb(Mg1/3Nb2/3)O3–0.3PbTiO3 (PMN-PT) substrates was investigated. A metal-insulator transition was observed at low temperature in LSMO/PMN-PT, which was ascribed to charge/orbital ordering (COO) formation due to a large tensile strain. The impact of strain modification on the transport properties around COO transition was investigated by using converse piezoelectric effect in PMN-PT. We found the magnetoresistance reduction due to the strain modification at COO state was much larger than that at disordering one, indicating the sensitivity of the COO phase to strain state. This fact presents a collateral evidence for the tensile strain origin of the COO transition.