In this paper, the networking architectures and information middleware of wireless sensor networks are developed to construct the heterogeneous information system platform for the real-time structural health monitoring application. The design and implementation of sensor firmware and networking middleware are the key study topics for WSN-based intelligent system platform. The networking gateway of system platform must be developed the independent and highly interoperability to integrate the heterogeneous networks. The application study combined with vibration sensing and GPS positioning is used to demonstrate the feasibility of the developed system platform. The middleware technology is implemented to filter and pre-process the received data from the Zigbee sensor node and extract the available information to transfer to and record in the system database. Moreover, the GPRS and GSM modules are used to be responsible for the long-distance and alarm message transmission on the information network, respectively. Furthermore, the integration system platform is constructed by integrating Zigbee sensor network, GPRS/GSM communication and LAN Internet to illustrate and evaluate the feasibility and performance of the proposed architecture for wireless sensor systems. In conclusion, the intelligent system platform of WSN-based monitoring system is developed and integrated to demonstrate and speed up the practical applications of wireless sensor networks in this paper.