This study is to develop a methodology and model to analyze the built-in speakers induced structural acoustic vibration of hard disk drive (HDD) in Notebook PC. First, a structural finite element (FE) model is built for the notebook PC to be analyzed using ANSYS. This FE model is subsequently verified by experiments. Second, the effects of acoustically transmitted and structurally transmitted oscillating forces, induced by the speakers, acting on the HDD, are investigated by acoustic FE model (SYSNOISE) and structural FE model. The acoustic transmission effect on the vibration of HDD is also investigated by experiment, which shows that the simulation results have a good agreement with experimental results. Finally, the effects of stiffness and damping ratio of the HDD supporters on the vibration of HDD are analyzed by the verified FE model.