In many hydrological studies and applications, it is desirable to know the absorption property of water bodies. In order to derive this inherent optical property of waters from remote sensing reflectance, a multiband quasi-analytical algorithm (QAA) was calibrated and validated for the highly turbid water of Taihu Lake in China. A data set collected on November 8, 2007, from Meiliang Bay of Lake Taihu was first used to calibrate a regional QAA algorithm for this area, and other two independent data sets, which were collected on August 22, 2006, and November 10, 2008, from the same area, were used to further validate the local algorithm. By shifting the reflectance wavelength from the red region to near infrared, the local QAA algorithm works well for this highly turbid water, the percent difference between the derived and measured absorption coefficients is less than 20% for all 13 samples in the data set of 2007, and most of them are less than 10%. The regional calibrated algorithm also has great result in deriving the absorption for the data set of 2008. However, the performance of the local algorithm also has various seasonal properties. It failed in deriving absorption for the data set of August 2006, unless the reference wavelength is shifted to even more long ones. It has been suggested in this paper that the seasonal and regional information is necessary for using the QAA algorithm in different optical property waters.