Data transmission in ad hoc networks involves interactions between medium access control (MAC)-layer protocols and data forwarding along network-layer paths. These interactions have been shown to have a significant impact on the performance of a system. This impact on multipath data transmission over multihop IEEE 802.11 MAC-based ad hoc networks is assessed; analysis is from a cross-layer perspective. Both MAC layer protocols and network-layer data forwarding are taken into account in the system models. The frame service time at source in a 802.11 MAC-based multipath data transmission system under unsaturated conditions is studied. Analytical models are developed for two packet generation schemes (round robin and batch) with a Poisson frame arrival process. Moreover, an analytical model is developed to investigate the throughput of a multipath transmission system in 802.11-based multihop wireless networks. Two methods are proposed to estimate the impact of cross-layer interactions on the frame service time in such a system. Two bounds of the system throughput are obtained based on these estimation methods. These models are validated by means of simulation under various scenarios.