A novel optimization procedure for the location of transmitting antenna in ultra-wideband (UWB) wireless communication systems is presented. The impulse responses of different transceiver locations are computed by ray-tracing techniques and inverse fast Fourier transform (IFFT). By using the impulse responses of these multi-path channels, the bit error rate (BER) performance for binary pulse amplitude modulation (BPAM) impulse radio UWB communication system are calculated. Based on the BER performance, outage probability of arbitrary region of receivers for any given location of the transmitter can be computed. The optimization of location of transmitting antenna in this paper is using nonuniform steady-state genetic algorithm (NU-SSGA) to minimize the outage probability. The optimization algorithm includes not only good searching accuracy but also calculating efficiency.