In this paper a performance analysis is carried out, in order to evaluate the possibility to employ power line communication (PLC) between secondary substations of a medium voltage (MV) distribution networks in a smart grid. The study is focused on the analysis of PLC technologies and the evaluation of the influence quantities on the communication performance in the most common case of by-pass connection at MV bus-bars of secondary substations. Different quantities have been analyzed as modulation techniques, requested bandwidth and bitrate, coupling device and system attenuation versus frequency in order to find the best solution for a reliable communication system. A complete model of a real case study, the distribution network of Ustica Island, have been carried out. Simulation results are presented and discussed.