The Mercury imaging X-ray spectrometer (MIXS) on board of ESA's fifth cornerstone mission BepiColombo will be the first space instrument using DEpleted P-channel FET (DEPFET) based detectors. The MIXS spectrometer comprises two channels with identical focal plane detectors and is dedicated to energy resolved imaging of X-ray fluorescence from the mercurial surface. We report on the characterization, integration, and spectroscopic qualification of MIXS flight detectors. Detector chips were precharacterized at die level in order to select the best dies for integration and to do homogeneity and yield studies. Then, the detector chips were integrated to MIXS Detector Plane Arrays (DPAs), a complicated process due to the sophisticated mechanical structure, which allows the thermal decoupling of the detector from its readout and control chips. After integration, spectroscopic qualification measurements were done in order to analyze the detector performance and to prove the excellent spectroscopic performance of the DEPFET Macropixel detectors over a wide temperature range. The integration and spectroscopic qualification of all flight grade modules is now successfully completed.