[Purpose] In order to strengthen hospital pharmacy management and guide drugs rational use, we introduce rational use and analysis software and embed it in the hospital information system (HIS). [Method] Establish drugs basic information and set using rights limit in the HIS. Implement online monitoring of antimicrobial drugs in real time and prompt rational use of the narcotic drugs, psychotropic drugs, and medicare drugs. [Result] The introduction of information technology in hospital makes the management for drugs using in accordance with the permission more simple and reliable especially in the narcotic drugs, psychotropic drugs, and medicare drugs using. Meanwhile, online monitoring of antimicrobial drugs in real time ensures antibiotics reasonable use. [Conclusion] The information technology makes us master the whole hospital drug use situation and achieve the goal of effective monitoring and scientific supervision on the clinical medication.