An efficient frequency domain soft interference cancellation (FD-SIC) scheme is proposed for turbo frequency domain equalization (FDE) in multiple-input multiple-output (MIMO) system. It is designed that at the receiver the inter-antenna interference (IAI) is cancelled by prior information in terms of data expectation. It can improve the input signal to interference and noise ratio (SINR) for the equalizer. Then block (data of one transmit antenna) wise frequency domain minimum mean square error (MMSE) equalization is implemented. Later a low complexity algorithm on the basis of single frequency tone (SFT) is deduced. Symbol Log-likelihood ratio (LLR) is calculated from the output of equalizer. Simulation results show that the proposed scheme has better link performance than traditional algorithms.