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Advanced mathematical models are now widely used in medical applications for diagnosis, prognosis, and prevention of diseases. This work looks at the application of advanced regression models for estimating key foot parameters in falls prevention research. Falls is a serious issue for the rapidly increasing elderly demographic. We propose to investigate the notion of falls prediction through the use of portable, light weight, easy to use and inexpensive sensors along with advanced computational intelligence estimation models. This study compares two mathematical models namely the Generalized Regression Neural Networks (GRNN), and the Support Vector Machine (SVM) to estimate the key gait parameters. The study deployed Inertial Measurement Units (IMU) consisting of accelerometers and gyroscopes sensors to measure the foot kinematics and an optoelectronic motion capture system to validate the results. Our results demonstrated that both mathematical models estimate the key end point foot trajectory parameters (1) mx1 - first maximum after toe-off (root mean square error (rmse) range of 2.0 mm to 12.5 mm) (2) normalized time to mx1 (rmse range of 0.4% to 3.7%) and (3) Minimum Toe Clearance (rmse range of 2.0 mm to 10.2 mm) and (4) normalized time to MTC (rmse range of 0.7% to 5.4%) using IMU features. The SVM regressor showed better estimation rmse 56 times out of the 70 comparison estimations. In all cases the best model respectively from the GRNN and SVM family of models was compared.