Electrical distribution network reconfiguration is a complex combinatorial optimization process aimed at finding a radial operating structure that minimizes the system power loss while satisfying operating constraints. In this paper, a harmony search algorithm (HSA) is proposed to solve the network reconfiguration problem to get optimal switching combination in the network which results in minimum loss. The HSA is a recently developed algorithm which is conceptualized using the musical process of searching for a perfect state of harmony. It uses a stochastic random search instead of a gradient search which eliminates the need for derivative information. Simulations are carried out on 33- and 119-bus systems in order to validate the proposed algorithm. The results are compared with other approaches available in the literature. It is observed that the proposed method performed well compared to the other methods in terms of the quality of solution.