Rapidly evolving businesses generate massive amounts of time-stamped data sequences and cause a demand for both univariate and multivariate time series forecasting. For such data, traditional predictive models based on autoregression are often not sufficient to capture complex nonlinear relationships between multidimensional features and the time series outputs. In order to exploit these relationships for improved time series forecasting while also better dealing with a wider variety of prediction scenarios, a forecasting system requires a flexible and generic architecture to accommodate and tune various individual predictors as well as combination methods. In reply to this challenge, an architecture for combined, multilevel time series prediction is proposed, which is suitable for many different universal regressors and combination methods. The key strength of this architecture is its ability to build a diversified ensemble of individual predictors that form an input to a multilevel selection and fusion process before the final optimized output is obtained. Excellent generalization ability is achieved due to the highly boosted complementarity of individual models further enforced through cross-validation-linked training on exclusive data subsets and ensemble output postprocessing. In a sample configuration with basic neural network predictors and a mean combiner, the proposed system has been evaluated in different scenarios and showed a clear prediction performance gain.