A RFID and wireless sensing network have been developed to improve a GHS-based intelligent management platform deployed on campus, which monitors the hazardous chemicals inventory at a number of laboratories. The developed RFID and wireless sensing system can automatically update the inventory of monitored chemicals periodically or respond the server's request instantly to check the usage and storage of the chemicals so that ignorance or misconduct of laboratory operators can be prevented or detected shortly to assure the safety of campus. Unlike the traditional RFID inventory control system, even the little quantity change in the chemical container can be detected and recorded to enhance the inventory control with the innovation of this system. This automatic system can be deployed and transmit data wirelessly in laboratories to minimize the cost and complexity of implementation. It also can communicate with the remote GHS-based management server via internet such that administration can oversee all the inventory of chemicals in the laboratories with this system installed. The implementation of this system has shown its effectiveness to improve the safety and accuracy of inventory control of the toxic chemicals on campus.