Tetris game is one of the most popular and interesting computer game. To reduce the cost and simply the circuit, a Tetris game system is developed base on single chip microcomputer and light-emitting diode dot matrix module. The hardware and application software of system are designed and the whole principle of various details in the system is described. The system including five parts: single chip microcomputer, address lock module, LED display module, input module and C51 program. The input module is composed of five keys through which one plays Tetris game. The address lock module uses 74ls373 chip to realize the multiplexing of P0 port. AT89S52 single chip microcomputer is used as the main control circuit for data processing. The software is developed in C language environment. The designed system is simulated with PROTEUS software. The external keys are simulated to control the movement of different form pieces when playing the game. It is indicated that this design can achieve the basic function of the game and realize the intended purpose. The system has many advantages such as small volume, very low cost, convenient usage and strong function.