A design methodology for the distributed microelectromechanical system (MEMS) impedance matching networks based on the optimization of the uniformity of the Smith chart coverage has been developed. The proposed approach was validated through a comparison between a traditional coplanar waveguide (CPW) design and an improved design based on a slow-wave (SW) structure. The enhanced reconfigurable impedance matching network has been developed for low-frequency applications. The network is based on a distributed MEMS transmission line (DMTL) coupled with the SW structure to reduce the total physical length of the network by 25% in comparison with a traditional DMTL. An extensive analysis was performed to identify the impact of each design parameter in order to optimize the structure and reduce the required size for relatively low-frequency applications. Several parameters are extracted from the electromagnetic simulation results and are used to design the proposed impedance matching network. Measurement results confirm the efficiency of the proposed design methodology in improving the impedance coverage and also miniaturization of the DMTL impedance matching networks.