In this paper, a framework for fusion approach to IGBT power module prognostics is reported. A failure modes, mechanisms, and effects analysis (FMMEA) for the IGBT power module is performed to identify critical failure mechanisms. For the failure mechanisms identified, relevant physics of failure models are discussed. In addition, the parameters affected by the critical failure mechanisms are identified that are to be monitored in application. The implementation of this prognostics approach involves precursor parameter monitoring, parameter isolation and trending, and the use of relevant physics of failure models for remaining useful life estimates.