A 0.13-mu m CMOS fourth-order notch filter for the rejection of the 5-6 GHz interference in UWB front-ends is reported. The filter is integrated into an analog front-end for Mode #1 UWB. A thorough analysis based on a simplified model of the filter is carried out. An algorithm for the automatic tuning and calibration of the filter is also discussed and demonstrated. Two versions of the circuit are designed and fabricated: the first comprises a low-noise amplifier and the filter, and the second expands it to a complete front-end. In the latter version the filter was also redesigned. The filter provides more than 35 dB of attenuation and has a tuning range of 900 MHz, adding less than 30% power consumption to the LNA. The out-of-band IIP3 (higher than -13.2 dBm with the filter off) takes a 9-dB advantage from the filter and the compression of the gain due to the out-of-band blocker is reduced by at least 6 dB in the complete front-end. The conversion gain of the front-end is 25 dB per channel, its average noise figure is lower than 6.2 dB, and its in-band 1-dB compression point is higher than - 30 dBm at a power consumption of 32 mW.