This paper deals with a wireless sensor network that was specifically designed to monitor temperature-sensitive products during their distribution with the aim of conforming to the cold-chain assurance requirements. The measurement problems and the constraints that have been encountered in this application are initially highlighted, and then, an architecture that takes such problems into account is proposed. The proposed architecture is based on specifically designed measuring nodes that are inserted into the products to identify their behavior under real operating conditions, e.g., during a typical distribution. Such product nodes communicate through a wireless channel with a base station, which collects and processes the data sent by all the nodes. A peculiarity of the product nodes is the low cost, which allows the information on the cold-chain integrity to be provided to the final customer. The results that refer to the functional tests of the proposed system and to the experimental tests performed on a refrigerated vehicle during a distribution are reported.