Principal component analysis (PCA) is a favorite multivariate statistical method for image enhancement and compression. However, it is well known that the classical PCA is sensitive to outliers and missing data. Fortunately, fuzzy statistics is an effective theory for processing these kinds of data. Fuzziness and randomicity are just the important characteristics of the data of remote-sensing images. Therefore, by introducing fuzzy statistics variables into classical PCA methods, a novel method for multispectral image processing called fuzzy-statistics-based PCA (FS-PCA) is proposed in this paper. To verify our proposed method, both the classical PCA and the FS-PCA are applied to the multispectral Landsat ETM+ data for image enhancement. The experimental results show that the differences among surface characteristics are expanded sufficiently and that the accuracy of surface feature recognition is improved greatly.