In this paper, we study the problem of anomaly detection in high-dimensional network streams. We have developed a new technique, called Stream Projected Outlier deTector (SPOT), to deal with the problem of anomaly detection from high-dimensional data streams. We conduct a case study of SPOT in this paper by deploying it on 1999 KDD Intrusion Detection application. Innovative approaches for training data generation, anomaly classification and false positive reduction are proposed in this paper as well. Experimental results demonstrate that SPOT is effective in detecting anomalies from network data streams and outperforms existing anomaly detection methods.