Gait modification is a noninvasive strategy for reducing the external knee adduction torque in patients with medial compartment knee osteoarthritis. Recently, a novel ldquomedial thrustrdquo gait pattern characterized by knee medialization during stance phase has been shown to reduce both adduction torque peaks significantly. While changes in footpath (i.e., toe out angle and stance width) also affect the adduction torque peaks, the extent to which footpath changes may alter the effectiveness of medial thrust gait is unknown. This study used a validated patient-specific computational model to investigate this issue. A dynamic optimization framework that accurately predicted adduction torque changes caused by knee medialization or footpath alteration for a specific patient was modified to predict the simultaneous effect of both factors. Medial thrust gait optimizations were then performed for the same patient using imposed footpath alterations consisting of all possible combinations of three toe out angles (nominal plusmn15deg) and three stance widths (nominal plusmn 50 mm). Overall, predicted adduction torque reductions produced by medial thrust gait were relatively insensitive to footpath alterations. The 32%-34% reduction in both peaks achieved with the nominal footpath was augmented by at most 9% and reduced by at most 3% for the altered footpaths. When combined with knee medialization, footpath alterations would likely have only a secondary effect on knee adduction torque reductions for this particular patient.