Summary form only given. We propose CARUSO - a new SoC approach that emphasizes connectivity, autonomic computing principles, real-time, and ultra-low power requirements. The requirements shall be fulfilled by a multithreaded processor core within a reconfigurable SoC. A helper thread running with low priority in an own thread slot concurrent to the application implements an autonomic manager that monitors the application. A middleware decides if self-optimization, self-configuration, self-protection, or self-healing techniques must be triggered based on the autonomic manager's information and further application knowledge.