A new adaptive nonlinear guidance law is proposed here. The fourth order state equation for integrated guidance and control loop is formulated taking into consideration the target uncertainties and control loop dynamics. The state equation is further changed into the normal form by nonlinear coordinate transformation. Using the normal form of state equation, an adaptive nonlinear guidance law is proposed to compensate for the uncertainties in both target acceleration and control loop dynamics. The proposed law adopts the sliding mode control approach with adaptation for unknown bound of uncertainties. The present approach can effectively solve the existing guidance problem against target maneuver and the limited performance of control loop. We have provided the stability analyses and performed simulations comparing favorably our approach to the state of the art.