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Synthesizing Biofunctionalized Nanoparticles to Image Cell Signaling Pathways
Hernandez-Sanchez, B.A.
Boyle, T.J.
Lambert, T.N.
Daniel-Taylor, S.D.
Oliver, J.M.
Wilson, B.S.
Lidke, D.S.
Andrews, N.L.
Adv. Mater. Lab., Sandia Nat. Labs., Albuquerque, NM;
This paper appears in: NanoBioscience, IEEE Transactions on
Publication Date: Dec. 2006
Volume: 5,
Issue: 4
On page(s): 222-230
ISSN: 1536-1241
INSPEC Accession Number: 9247476
DOI: 10.1109/TNB.2006.886565
Posted online: 2006-11-30 10:48:53.0
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This minireview outlines the synthetic efforts, from our research group, to produce nanomaterials for use as imaging agents to study cell signaling pathways. An overview of our approach to the synthesis and biofunctionalization of metal, semiconductor, and ceramic nanomaterials is presented. The probes investigated include coinage metals, Cd-based, Gedeg, naturally occurring fluorescent (NOF) minerals, and Ln-based nanoparticles which were synthesized from novel metal alkoxide, amide, and alkyl precursors. We illustrate the applications of some of these materials as imaging probes to detect signaling pathway components and cellular responses to signals (apoptosis and degranulation) in inflammatory and cancer cells
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Controlled Indexing
bioceramics
biomedical optical imaging
cadmium compounds
cancer
cellular biophysics
nanobiotechnology
nanoparticles
reviews
semiconductor quantum dots
Non-controlled Indexing
Cd-based nanoparticles
Ge
Ln-based nanoparticles
alkyl precursors
amide
apoptosis
biofunctionalization
biofunctionalized nanoparticles
cancer cells
cell signaling pathway imaging
cellular responses
ceramic nanomaterials
coinage metals
degranulation
inflammatory cells
metal alkoxide
minireview
naturally occurring fluorescent mineral
semiconductor
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Apoptosis
biofunctionalization
degranulation
imaging nanoprobes
nanoceramics
nanometals
quantum dots
synthesis
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Cell Physiology
Contrast Media
Diagnostic Imaging
Image Enhancement
Molecular Probe Techniques
Nanoparticles
Particle Size
Quantum Dots
Signal Transduction
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