In situ characterization of biofluid using an optimized hybrid acousto-optic sensor array on a microfluidic cell

The present work deals with the development of an integrated microfluidic platform which address several challenges. The sensor array combines a dual Rayleigh wave and Love wave acoustic device with SPR for biomedical diagnosis. Based on simulations and mechanical studies, we optimized the microfluidic cell to limit disturbances to the Love wave. We also studied different combinations of crystal cuts (Quartz-AT, LiNbO3-36YX) and ZnO waveguide thickness to enhance the sensitivity. The results confirm the idea that the whole measurement system must be considered in order to develop an integrated analysis set-up with optimal operation.