Model free control based nonlinear integral-backstepping control for blood glucose regulation

In this paper, a Model Free Control based Nonlinear Integral Backstepping Control (MFC-NIB) strategy is developed and applied to blood glucose regulation systems, which is a typical biological system with parameter variations, uncertainties and external disturbances. Firstly, an Intelligent Proportional controller (iP), which is based on model-free theory and whose algebraic estimation technique is replaced by a Time-Delay Estimation(TDE) method is developed. Secondly, to improve the control convergence, the MFC-NIB is studied based on the proposed iP. Finally, to demonstrate the performance and effectiveness of the proposed method MFC-NIB, the simulations with comparisons with iP have been implemented on the referred glycemia regulation systems.