Subcellular electrode arrays for multisite recording of dopamine in vivo

We report the fabrication and use of carbon fiber (CF) arrays with 8 recording electrodes having individual diameters of 8-10 μm (9-10 times smaller than conventional sensors and state of art) for electrochemical recording of dopamine from deep brain regions in a minimally invasive and high density manner. Accordingly, key advancements demonstrated are (1) radical reduction in size and (2) potential for wide spatial distribution of concurrent electrochemical measurement in the brain.