Design considerations and clinical applications of closed-loop neural disorder control SoCs

This paper presents the closed-loop neural disorder control concept and some design considerations. Two architectures of closed-loop neuromodulation for Parkinson's disease and epileptic seizure are proposed. One is a closed-loop deep brain stimulator, which meets the IEC 60601-1 standard. The other one is an implantable SoC for epileptic seizure control, which is verified by animal experiment.