Self-powered glucose biosensor operating under physiological conditions

Here we describe the characterization of a self-powered glucose biosensor comprising of a multi-walled carbon nanotubes (MWCNTs) modified with pyroquinoline quinone glucose dehydrogenase (PQQ-GDH) bioanode and bilirubin oxidase biocathode at physiological conditions. The assembly shows an enhancement in peak power and current densities as compared to the self-powered glucose biosensor comprising of PQQ-GDH bioanode and laccase biocathode. The assembly produced a maximum open circuit voltage of 480.1 mV and short circuit current density of 640 μA/cm
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with a peak power density of 89.27 μW/cm
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. The self-powered glucose biosensor exhibited an extended linear dynamic range of 0.1 mM to 35 mM with a sensitivity of 12.221 Hz/mM cm
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. The use of bilirubin oxidase as the cathodic enzyme in addition to the design of biofuel cell assembly makes it a viable candidate as a potential power source for bioelectronics devices.