Reproducible functionalization of silicon substrates intended for biomedical applications

This paper describes the functionalization of silicon substrates in hydrolyzed (3-Aminopropyl) triethoxysilane (APTES) solution and in vapour-phase. The FTIR spectra of silicon samples submitted to silanization revealed specific bands associated to siloxane, primary and secondary amine groups, and with methylene groups, which demonstrate the success of APTES functionalization. The FTIR spectra of treated Si-APTES-glutaraldehyde exhibit absorption bands assigned to carbon-nitrogen bond, carbon-oxygen bond and methylene groups, thus, demonstrating the efficiency of crosslinking on the substrates which were silanized by using both approaches.