Identification of therapeutic inhibitors for the treatment of oral cancer using herbal bio-active principles by means of computational approach

Oral cancer is a type of cancer which targets mouth and surrounding tissues. It includes, lips, cheeks, tongue, sinuses, throat. Oral cancer could be life threatening, if not diagnosed in early stages. American Cancer Society says that men are at more risk than women. Oral cancer can be treated like any other cancers. But still the efficacy of the drugs is questionable. Hence, an attempt was tried to find the suitable inhibitors for the treatment of oral cancer using bioactive principles of Cissus quadrangularis, targeting SIRT3, P21 and P53. The Resveratol in Cissus quadrangularis has showed very good interaction with two target proteins involved in oral cancer viz., SIRT3 and P21. Resveratol also has very good pharmacodynamic and pharmacokinetic properties. This study concludes that Resveratol in Cissus quadrangularis has the potential to serve as an anticancerous drug. However, the results might be validated through in-vivo and in-vitro studies to prove the efficacy of the active compounds and to protect the mankind from oral cancer.